Imipenem is a broadspectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. The dosage of primaxin in adult patients should be based on suspected or confirmed pathogen susceptibility. There are no data regarding peritoneal dialysis or hemofiltration. Imipenem and meropenem, aztreonam, vancomycin flashcards. Merrem iv meropenem dosing, indications, interactions. Seek emergency medical attention or call the poison help line at 18002221222. For hemodialysis patients, the recommended dose is 500 mg iv once daily, given at least 6 hours before hemodialysis. Assessment of an alternative meropenem dosing strategy. Pharmacology, adverse reactions, warnings and side effects. Imipenem and cilastatin for injection usp page 1 of 43 product monograph pr imipenem and cilastatin for injection usp imipenem and cilastatin for injection imipenem cilastatin sodium, 250 mg250 mg for injection imipenem cilastatin sodium, 500 mg500 mg for injection sterile powder for iv infusion must be diluted before use.
Sterile powder for iv infusion must be diluted before use therapeutic classification antibiotic. In mice, ataxia and seizures were seen, with much lower blood concentrations of imipenem than cefotaxime or benzylpenicillin 1900. Imipenem and cilastatin combination is used in the treatment of infections caused by bacteria. Imipenemcilastatin side effects, dosage, interactions. Each 125 mg, 250 mg, or 500 mg dose should be given by intravenous administration over 20 to 30 minutes. Accidental release measures contain spill and collect, as appropriate. See full prescribing information for dosage recommendations in pediatric patients 2. The dosage recommendations for primaxin represent the quantity of imipenem to be administered. Tbinfected mice were treated with isoniazid or imipenem to compare the efficacy of the two drugs. After a single intravenous dose of merrem iv, the highest mean concentrations of meropenem were found in tissues and fluids at 1 hour 0. Cilastatin helps imipenem work more effectively by preventing the breakdown of the antibiotic in the kidneys. Dosage regimen based on creatinine clearance mlminute1. Drugs az pill identifier supplements symptom checker diseases dictionary media.
Imipenem and cilastatin monograph for professionals. We evaluated probability of target attainment and cumulative probability of target attainment of 30min and 3h infusions for imipenem cilastatin and meropenem. Ten mdr tbinfected patients were treated with imipenem in combination with other first or secondline drugs. Dailymed primaxin iv imipenem and cilastatin sodium. Dosage may be increased to max 4 g daily or 50 mgkg daily, whichever is lower. Product monograph pr imipenem and cilastatin for injection usp. Imipenem and cilastatin sodium definition of imipenem and. It works by killing bacteria or preventing their growth. Sep 06, 2019 the dosage of primaxin in adult patients should be based on suspected or confirmed pathogen susceptibility. Dosage of primaxin, if the infection is suspected or proven to be due to a susceptible bacterial species. For intravenous injection only the dosage of primaxin in adult patients should be based on suspected or confirmed pathogen susceptibility as shown in table 1 below. Imipenem and cilastatin intravenous route, intramuscular. Imipenemcilastatin an overview sciencedirect topics. I did a search and could not find a reference in which nonirritating concentrations of those antibiotics were evaluated.
Imipenem for dogs uses and side effects second opinion doctor. Start studying imipenem and meropenem, aztreonam, vancomycin. Compatibility of imipenem cilastatin sodium with commonly used intravenous solutions. Find out what health conditions may be a health risk when taken with imipenem cilastatin intravenous.
Approximately 70% of the cilastatin sodium dose is recovered in the urine within 10 hours of administration of primaxin. Imipenemcilastatin primaxin renal dosing webpage on the internet. This medication is given by injection into a muscle or vein, usually every 6 to 8 hours or as directed by your doctor. Imipenem for dogs uses and side effects second opinion. Imipenem and cilastatin sodium 250mg prescription and dosage sizes information for physicians and healthcare professionals. Urine concentrations of imipenem in excess of 10mcgml can be maintained for up to 8hours with primaxin at the 500mg dose. Evaluation of the appropriateness of imipenemcilastatin. Due to inconsistencies between the drug labels on dailymed and the pill images provided by rximage. Imipenem 500mg q8h meropenem 500mg q8h imipenem 1g q8h meropenem 500mg q6h imipenem 750mg q12h meropenem 500mg q8h imipenem 250mg q6h meropenem 500mg q8h see full protocol details online for pediatric and renal dosage adjustment.
Imipenem is commonly used in combination with and is now available in a triple drug product with cilastatin and which was recently approved by the fda. Comparison of 30min and 3h infusion regimens for imipenem. Primaxin iv injection summary of product characteristics. Includes dosages for bacterial infection, urinary tract infection, bronchitis and more. Antiinfective pregnancy risk category c action acts against many grampositive and gramnegative organisms by binding to bacterial cell wall, causing cell death. It is commercially available as primaxin as 250mg or 500mg infusion bottles for iv use or 500mg or 750mg vials of lyophilized powder for im injection. Administer by intermittent iv infusion and by deep im injection. The daily dose of primaxin should be based on the type of infection and given in equally divided doses based on consideration of degree of susceptibility of the pathogens and the patients renal function see also section 4. Invanz ertapenem dosing, indications, interactions. This drug is not approved for use in animals by the food and drug administration but it is prescribed legally by veterinarians as an extralabel drug. This medicine will not work for colds, flu, or other virus infections imipenem and cilastatin combination is used to treat infections in many different parts of the body.
Imipenemrelebactamcilastatin versus piperacillintazobactam. The pseudomonas is sensitive to imipenem and meropenem. Addition of cilastatin prevents renal inactivation of imipenem, resulting in increased. Contraindications for imipenemcilastatin intravenous. Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis infection of the heart lining and valves and respiratory tract including pneumonia, urinary tract, abdominal stomach area, gynecological, blood, skin, bone, and joint infections. Urine concentrations of imipenem in excess of 10 mcgml can be maintained for up to 8 hours with primaxin at the 500mg dose. Meropenem versus imipenemcilastatin as empirical monotherapy. Imipenem cilastatin dosage follow all directions on your prescription label. Imipenemcilastatin sodium at doses of 2525 and 100100 mgkg, iv induced no. Like all lactam antibiotics, meropenem interferes with. The alternative meropenem dosage of 500 mg every 6 hours yielded similar patient outcomes, including time to defervescence, need for additional antibiotics, duration of therapy, and mortality, when compared with the traditional meropenem dosage and imipenem cilastatin in adults with febrile neutropenia. Meropenem is a semisynthetic lactam antibiotic that belongs in the penicillinbased group of drugs called carbapenems.
Common and rare side effects for imipenemcilastatin. The dose recommendations for primaxin represent the quantity of imipenemcilastatin to be administered. Do not administer im preparation or drug reconstituted for im administration iv. Cilastatin prevents the metabolism of imipenem by renal tubular dipeptidase. Eighteen healthy adults in a randomized, 4phase, crossover study received mg of imipenem cilastatin or meropenem as a single dose iv over 30 min or 3 h. Imipenemcilastatin sodium is hemodialyzable see overdosage. Drug information on primaxin im, primaxin iv, primaxin iv addvantage imipenem and cilastatin includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. A reduction in dose must be made for a patient with a creatinine clearance of less than 90mlmin2. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Generally, veterinarians may administer imipenem after firstline antibiotics such as amoxicillin, and have been proven ineffective. Call your doctor for instructions if you miss a dose. Additional doses of 500 mg may be given at 8 and 16 hr after induction if needed. Treatment adult w normal renal function most infections. Evaluation of the appropriateness of imipenemcilastatin prescription. Burkholderia pseudomallei melioidosis unlabeled use. Imipenem cilastatin and meropenem are carbapenem antibiotics that are infused intravenously iv over 30 to 45 min. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Imipenemcilastatin by injection national library of. A population pharmacokinetics analysis using a 2compartment iv infusion model was performed. In a doseranging study of smaller premature infants 6701,890 g in the first week of life, a dose of 20 mgkg q12h by 1530 minutes infusion was associated with mean peak and trough plasma imipenem concentrations of 43 mcgml and 1.
If administered within 6 hours before hemodialysis, a supplementary dose of 150 mg is recommended after the hemodialysis session. For adult patients with normal renal function creatinine clearance of greater than or equal to 90 mlmin, the recommended dosage regimens are. Find information about common, infrequent and rare side effects of imipenem cilastatin intravenous. Each reconstituted 250 mg or 500 mg dose should be given by intravenous. First generic version of key antibiotic to launch in united states. Imipenem cilastatin sodium is hemodialyzable see overdosage 10. Compatibility of imipenemcilastatin sodium with commonly. Is there any information available on the nonirritating concentrations of imipenem andor meropenem for intradermal testing. By continuing to browse this site you are agreeing to our use of cookies.
What happens if i overdose primaxin im, primaxin iv, primaxin iv addvantage. Medscape indicationspecific dosing for primaxin imipenemcilastatin. The most common side effects of imipenem are diarrhea, nausea, vomiting, skin rash, pruritus, and injectionsite reactions. A multicenter, openlabel, randomized, parallelgroup trial was conducted in belgium, evaluating empirical monotherapy with meropenem or imipenem cilastatin both 1 g8 h intravenously in icu patients with one or more of the following infections caused by sensitive pathogens.
Imipenem definition is a semisynthetic carbapenem antibiotic c12h17n3o4sh2o that is derived from a bacterium streptomyces cattleya and is effective against gramnegative and grampositive bacteria. Renal dosage adjustment guidelines for antimicrobials the pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance generally using the cockroftgault equation for patients. This is the first study conducted at this hospital that evaluates the appropriateness of imipenemcilastatin prescription empirically, its dosage and dosing adjustment whenever required before and after culture results, and the rate of occurrence of seizures in the study patients. Primaxin imipenemcilastatin dosing, indications, interactions. Imipenem is a broadspectrum, semisynthetic betalactam carbapenem derived from thienamycin, produced by streptomyces cattleya. The results of the study, which were published in 2005, indicate that imepenemcilastatin is active against drugresistnat tb. Imipenem binds to and inactivates penicillinbinding proteins pbps located on the inner membrane of the bacterial cell wall. These highlights do not include all the information needed to.
Imipenem and cilastatin for injection food and drug. Imipenem cilastatin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. Renal dosage adjustment guidelines for antimicrobials. For patients not taking glucuronidation inducers, may need to increase or decrease lamotrigine dose if atazanavirritonavir is added or discontinued, respectively. Nov 09, 2018 imipenem is an antibiotic that fights bacteria. Jan 01, 2017 imipenem and cilastatin combination is used in the treatment of infections caused by bacteria. Because imipenem is rapidly inactivated by renal dehydropeptidase i, it is given in combination with cilastatin, a dhpi inhibitor which increases halflife and tissue penetration of imipenem. The dose recommendations for primaxin represent the quantity of imipenem cilastatin to be administered. Detailed cilastatin imipenem dosage information for adults and children. Find patient medical information for primaxin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Imipenem and cilastatin dosage in renal impairment reduced i. The results of the study, which were published in 2005, indicate that imepenemcilastatin is active against drug resistnat tb. An equivalent amount of cilastatin is also present in the solution. To reduce the development of drugresistant bacteria and maintain the effectiveness of primaxin i.
The dosage of primaxin in adult patients should be based on suspected or confirmed pathogen susceptibility as shown in table 1 below. Imipenem for dogs uses and side effects imipenem is a powerful antimicrobial drug used to combat a number of infections in dogs. Webmd provides common contraindications for imipenem cilastatin intravenous. Approximately 70% of the cilastatin sodium dose is recovered in the urine within 10hours of administration of primaxin.